The Development of A3-Coupling (Aldehyde-Alkyne-Amine) and AA3-Coupling (Asymmetric Aldehyde-Alkyne-Amine)

Preparation of Ag2S Nanoparticles and using as Catalyst for the A3-coupling (Aldehyde-Amine-Alkyne) Reaction

Microwave assisted facile one-step approach was adopted to prepare mono-dispersed silver sulfide nanoparticles. The structures of the synthesized Ag2S nanoparticles were confirmed by Fourier-transform infrared spectroscopy (FT-IR), diffuse reflectance UV-vis spectroscopy (DRS), X-ray diffractometer (XRD), energy dispersive X-ray analysis (EDX) and transmission electron microscope (TEM). The pre...

Tandem aldehyde–alkyne–amine coupling/cycloisomerization: A new synthesis of coumarins

Cu-catalyzed A(3) coupling of ethoxyacetylene, pyrrolidine and salicylaldehydes led to a concomitant cycloisomerization followed by hydrolysis of the resultant vinyl ether to afford coumarins in a cascade process. The reaction proceeded through exclusive 6-endo-dig cyclization and is compatible with halo and keto groups giving coumarins in good to moderate yields.

An Efficient Synthesis of Benzylamino Coumarin Derivatives via Three-component Coupling of 4-hydroxycoumarin, Aromatic Aldehyde and Cyclic Secondary Amine Catalyzed by CuO Nanoparticles

A green and efficient one-pot synthesis of benzylamino coumarin derivatives was conducted by a three-component condensation of 4-hydroxycoumarin, cyclic secondary amine, and aromatic aldehyde in the presence of CuO nanoparticles (NPs) as a heterogeneous catalyst in water at room temperature. 

A Convenient Reagent for Aldehyde to Alkyne Homologation.

An convenient reagent for the one-carbon homologation of an aldehyde to the corresponding alkyne is reported. This reagent allows this conversion to conveniently be carried out on a large scale under ambient conditions.

an efficient synthesis of benzylamino coumarin derivatives via three-component coupling of 4-hydroxycoumarin, aromatic aldehyde and cyclic secondary amine catalyzed by cuo nanoparticles